The Malankara Orthodox Syrian Church (M.O.S.C.) College of Nursing, Kolenchery, was established in 2006 under the management of the M.O.S.C. Medical Mission, a charitable institution registered in 1970 under the Travancore-Cochin Literary, Scientific and Charitable Societies Act. Since its inception, the college has grown into one of the most distinguished institutions in Kerala for nursing education and training.

The college is recognized by the Indian Nursing Council (INC), New Delhi, and the Kerala Nurses and Midwives Council (KNMC), Thiruvananthapuram, and is affiliated with the Kerala University of Health Sciences (KUHS), Thrissur.

M.O.S.C. College of Nursing comprises six full-fledged academic departments:

• Medical-Surgical Nursing
• Pediatric Nursing
• Psychiatric Nursing
• Community Health Nursing
• Obstetrics and Gynecologic Nursing
• Nursing Foundations

Currently, the college offers the following academic programs:

• B.Sc Nursing – Annual intake of 90 students
• M.Sc Nursing – Intake of 8 students in Medical-Surgical Nursing, Pediatric Nursing, Psychiatric Nursing, Obstetrics and Gynecologic Nursing (2 in each specialty)

The college is also recognized as a Ph.D. research center under the Kerala University of Health Sciences, Thrissur, reinforcing its commitment to academic advancement and research in the field of nursing.

In addition to its academic achievements, the college has been recognized for its various initiatives, including:

• Quality Assurance System (QAS) A+ Accreditation
• 6th rank in the Kerala Institutional Ranking Framework (KIRF)
• One Star rating from the Institute Innovation Council (IIC)
• A++ certified Social Entrepreneurship, Swachhta and Rural Engagement Cell (SES REC), recognized by the Mahatma Gandhi National Council of Rural Education (MGNCRE) under the Government of India's Ministry of Education.

These recognitions highlight the institution's dedication to social responsibility, sustainability, and rural health initiatives.